• Osteopenia
• Bone spur
• Bone fracture
• Nerve and muscle pain.
• Fibromyalgia
• Arthritis: (Osteoathritis, Rheumatoid arthritis)

Post Menopausa: After menopause and the loss of estrogen, the inner mesh of bones becomes thinner, weaker and more brittle over the years. It can be measured by a bone density scan.

Growing children: The Calcium demand is great in children during skeletal growth and decreases gradually with advancing age.

Pregnancy and Lactation
During pregnancy Calcium transport from the mother to the fetus takes place across the placenta and challenges calcium concentration of out side supplementation is not taken and diet is not adequate in calcium bone become brittle. Furthermore during lactation further loss of calcium take place due to supply of calcium mother               plasma Calcium level can significantly drop due to calcium excretion into the milk.

Indication And Usage

• During Pregnancy and Lactation
• For Post-menopausal Women
• Osteoporosis/ Osteopenia
• Rickets
• Calcium Deficiency
• Vit-D Deficiency

Contraindications
Calcium Aspartate is contraindicated in following conditions:

• Renal calculi
• Hypercalcaemia
• Hyperparathyroidism
• Hypervitaminosis D
• Cancer
• Hypersensitivity to the drug or any of its ingredients

Direction to the Target Tissue
Just getting Calcium in to the blood stream doesn’t  guarantee that the calcium can be directed to any particular tissue. It is clinically most important to know whether the calcium is actually “directed” to the target cells. This is because it is observed that even adequate supplementation of organic calcium preparations fail to increase bone mineral density (BMD) e.g., in athletes. The mechanism for this phenomenon is not completely understood, but stability of calcium in blood stream is thought to contribute.

Types of Calcium Supplementations Available

1. Inorganic:  Calcium carbonate, Calcium hydroxide/ oxide etc.
2. Organic :    Calcium Aspartate Anhydrous, Calcium citrate maleate, Calcium lactate etc.

Limitations of Current Calcium Supplementations
Biological utilization of calcium includes its absorption, transport in the blood stream and directed delivery in to the tissues. But thr current calcium preparations are not able to fulfill either one or all criteria for an effective biological utilization of calcium, which is because of following reasons:-

1. pH dependent calcium absorption.
Conventional Calcium salts contain calcium which is bonded to anions like carbonate etc., hence are soluble only at acidic pH 4-7, which is available only in upper GIT e.g., in stomach. They get precipitated in small intestine at higher pH.

2. Vitamin-D dependent absorption.

3. Low absorbable calcium & bioavailbility.

4. Need to supplent Magnesium.

5. Instability/ precipitation and side effects.

6. Need to take with food.

Due to requirement of acidic pH for absorption

Supplemental Calcium taken without food may increase the risk of kidney stones in women and possibly also in men. It is thought that taking supplemental calcium without food limits the opportunity for the beneficial effects that calcium may have in binding oxalatein the intestine. Those at risk or form calcium-containing kidney stones are generally advised not to take supplemental calcium. Those with achlorhydria should take calcium aspirate with food.

End Stage Renal Failure: It is recommended to avoid the usage of calcium aspartate at the end stage renal failure.
 
Hypoparathyroid Patients: Patients with hypoparathyroid symptoms should avoid consuming calcium aspartate.
Prolonged Use: Like other calcium supplements, prolonged usage of calcium aspartate may lead to milk-alkali syndrome, nephrocalcinosis and renal insufficiency.

Adverse Drug Reactions
Calcium preparation branded are generally well tolerated. Though in few cases like other tonics may cause constipation, bloating, gas, flatulence, abdominal pain, dry mouth, thirst, polyuria, confusion and delirium.